What is INFAT®PRO
INFAT®PRO is specially formulated to reach a higher concentration* of palmitic acid in the middle position of the triglyceride than INFAT®, and by adding INFAT®PRO to the formula, sn-2 palmitate level will be even closer to human milk.
Benefits of Higher sn-2 Palmitate Concentration
Higher concentration of sn-2 palmitate, and thus higher absorption of palmitic acid, has been shown in several studies to reduce the formation of calcium soaps in baby’s stool [1-3]. With INFAT®PRO, manufacturers can offer infant formulas with improved fat composition.
Clinical Studies and Absorption Correlation
A review of the clinical studies of infants fed formulas with increased levels of sn-2 palmitate has shown a relationship between levels of sn-2 palmitate and fatty acid and calcium absorption [2].
Figure 1 shows the correlation between the level of sn-2 palmitate (C16:0) out of total palmitic acid in infant formula, plotted against fatty acid and calcium absorption calculated as a modified Cohen’s effect size. The results show that progressively increasing level of C16:0 at sn-2 position on the triglycerides, leads to a dose-dependent increase in both fat and calcium absorption. The reduction in fecal calcium soaps is accompanied by a decrease in the incidence of harder stools.
The percentage of C16:0 in formula triglycerides (x-axis) was plotted against the mean percentage of C16:0 absorption (green circles) or calcium (blue circles) reported in clinical studies with preterm and term infants to derive the Cohen effect.
Palmitic acid at sn-2 position of total palmitic acid (%)
Figure 1: Modified Cohen’s effect size of the effect of the 16:0 position in formula triglycerides on the absorption of 16:0 and calcium in
term and preterm infants. Graph was adapted from Bar-Yoseph et al [2].
*INFAT®PRO is offered with minimum 60% sn-2 palmitate in the concentrate
References
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Bar-Yoseph, F. J Pediatr Gastroenterol Nutr, 62(2), 341. 2016. -
Bar-Yoseph, F. Prostaglandins Leukot Essent Fatty Acids, 89(4), 139-143. 2013. -
Havlicekova, Z. Nutr J, 15, 1-8. 2015.
